bovis - Articles
Bacitracin
Introduction
In the UK, Bacitracin is classified as category D (Prudence) by the European Medicines Agency (EMA).
Name
- Bacitracin methylene disalicylate.
Class of drug
- Polypeptide antibiotic.
- European Medicines Agency (EMA) category D (prudent use) in the categorization of antibiotics for use in animals for prudent and responsible use.
Description
Chemical name
- (4R)-5-[[(2S,3S)-1-[[(2S)-6-amino-1-[[(2R)-5-amino-1-[[(2S,3S)-1-[[(2R)-1-[[(2S)-1-[[(2R)-1-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoic acid;(2-hydroxybenzoyl)oxymethyl 2-hydroxybenzoate.
Molecular formula
- C81H117N17O23S.
Molecular weight
- 1729.0.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed Papers
- Recent references from PubMed and VetMedResource.
- Thompson A J, Smith Z K, Sarturi J O & Johnson B J (2021) Antimicrobial supplementation alters digestibility and ruminal fermentation in a continuous culture model. J Appl Anim Res 49 (1), 23-29 TaylorFrancis.
- Van Nevel C J & Demeyer D I (1992) Influence of antibiotics and a deaminase inhibitor on volatile fatty acids and methane production from detergent washed hay and soluble starch by rumen microbes in vitro. Anim Feed Sci Technol 37, 21–31 ScienceDirect.
- Russell J B & Strobel H J (1988) Effects of additives on in vitro ruminal fermentation: a comparison of monensin iand bacitracin, another gram-positive antibiotic. J Anim Sci 66 (2), 552–558 PubMed.
- Spires H R & Algeo J W (1983) Laidlomycin butyrate - an ionophore with enhanced intraruminal activity. J Anim Sci 57 (6), 1553–1560 PubMed.
Other sources of information
- The Veterinary Formulary (2001) 5th edn. Ed: Bishop Y. British Veterinary Association and Pharmaceutical Press.
- Veterinary Pharmaceuticals and Biologicals (1999/2000) 11th edn. Veterinary Medicine Publishing Group.
- National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
-
European Medicines Agency (online) Categorisation of Antibiotics for Use in Animals for Prudent and Responsible Use. Website: www.ema.europa.eu (pdf download).
Organisation(s)
- National Office of Animal Health (NOAH) Website: www.noahcompendium.co.uk.
- US Food & Drug Administration (FDA) Website: www.fda.gov.
- Veterinary Medicines Directorate (VMD) Website: www.vmd.defra.gov.uk.
- Zoetis US Website: www.zoetisus.com.