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Familial acantholysis
Introduction
- Cause: inherited.
- Signs: erosions and ulcerations.
- Diagnosis: histopathology.
- Treatment: none.
- Prognosis: grave.
Presenting signs
- Affected calves show erosions and ulcerations. These can be anywhere on skin but particularly over pressure points, the muzzle and in the mouth and also at the coronary bands and over the carpi.
Acute presentation
- May be separation of the hooves.
Geographic incidence
- Reported in New Zealand.
Age predisposition
- Symptoms present at birth or within 2 weeks of birth.
Breed/Species predisposition
- Reported in Angus calves Aberdeen angus, Brangus and Red Belgian cattle.
Pathogenesis
Etiology
- Probably an autosomal recessive inherited trait in Angus calves.
Pathophysiology
- Defective collagen bridging in deep dermal layers with abnormal development of desmosomes and tonofilaments.
- Leads to acantholysis and skin loss.
Timecourse
- Affected calves do not survive.
Diagnosis
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Treatment
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Prevention
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Outcomes
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Further Reading
Publications
Refereed Papers
- Recent references from PubMed and VetMedResource.
- Hill F (2003) A triad of bovine inherited diseases. NZ Vet Med J 51 (1) 46 PubMed.
- Jolly R D et al (1973) Familial Acantholysis of Angus calves. Vet Pathol 10, 473 PubMed.
Other sources of information
- Scott D W (1988) Large Animal Dermatology. W B Saunders, USA.