bovis - Articles
Digoxin
Synonym(s): Cardiac gylcoside
Introduction
Name
- Digoxin.
Class of drug
- Myocardial stimulant, cardiac glycoside.
At the time of publication there is no published Maximum Residue Limit (MRL) for Digoxin and therefore this drug should NOT be used in food producing animals. The information given below is for interest only and Vetstream advise against using digoxin in cattle or other animals destined for human consumption.
Description
- Discontinue digoxin therapy.
- Determine serum electrolyte concentrations and acid-base status and treat with fluids appropriately Fluid therapy: overview.
- Potassium can be administered if there is a life-threatening dysrhythmia, unless there is a high degree AV block.
- Lidocaine Lidocaine may be used for worsening ventricular arrhythmia that cause the animal to be hemodynamically unstable.
- If symptomatic, sinus bradycardia, sinoatrial arrest and 3rd degree AV block usually respond to atropine administration.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed Papers
- Recent references from PubMed and VetMedResource.
- Koritz J D, Anderson K L, Neff-Davis C A, Wilcke J R & Davis L E (1983) Pharmacokinetics of digoxin in cattle. J Vet Pharmacol Ther 6 (2), 141-147 PubMed.
Other sources of information
- Commission Regulations (EU) No 37/2010 of 22 December 2009. On pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin: https://ec.europa.eu.
- Yolande Bishop (2005) Ed The Veterinary Formulary. 6th edn. Published in association with the British Veterinary Association. pp 239-240.
- Plumb D C (2002) Veterinary Drug Handbook. 4th edn. Published by Iowa State Press, Ames, Iowa, USA.