bovis - Articles
Phenylbutazone
Synonym(s): Bute
Introduction
Name
- Phenylbutazone.
Class of drug
- Non-steroidal anti-inflammatory drug (NSAID).
Description
Chemical name
- 4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione.
Molecular formula
- C19H20N2O2.
Molecular weight
- 308.374 g/mol.
Physical properties
- Lipophilic.
Storage requirements
- Room temperature.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Anderson D E, Edmondson M A (2013) Prevention and Management of Surgical Pain in Cattle. Vet Clin North Am Food Anim Pract 29 (1),157-184 PubMed.
- Authie E C et al (2010) Effect of an endurance-like exercise on the disposition and detection time of phenylbutazone and dexamethasone in the horse: Application to medication control. Equine Vet J 42 (3), 240-247 PubMed.
- Sabate D, Homedes J, Salichs M, Sust M & Monreal L (2009) Multicentre, controlled, randomised and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses. Equine Vet J 41 (7), 700-705 PubMed.
- Conwell R & Stratford C (2008) Right dorsal colitis. Vet Rec 13 (8), 7-10.
- Lees P Maitho T E, Ayliffe T, Taylor J B O (1988) Pharmacokinetics, metabolism and excretion of phenylbutazone in cattle following intravenous, intramuscular and oral administration. Res Vet Sci 44 (1), 57-67 PubMed.
- Eberhardson B, Olsson G, Appelgren L, Jacobsson S O (1979) Pharmacokinetic studies of phenylbutazone in cattle. J Vet Pharm Therap 2 (1), 31-37.
Other sources of information
- Plumb's Veterinary Drug Handbook.
- Food and Drug Administration. Department of Health and Human Services (2003) New Animal Drugs; Phenylbutazone; Extralabel Animal Drug Use; Order of Prohibition.
- Derived from The Veterinary Formulary. 4th edn (1998) Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.